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Anna Bratasz Selected Research

(3,5- bis((4- fluorophenyl)methylidene)- 1- ((1- hydroxy- 2,2,5,5- tetramethyl- 2,5- dihydro- 1H- pyrrol- 3- yl)methyl)piperidin- 4- one)

9/2010HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.
5/2010Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells.
5/2010Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts.
6/2009Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression.

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Anna Bratasz Research Topics

Disease

21Neoplasms (Cancer)
01/2020 - 09/2004
8Ovarian Neoplasms (Ovarian Cancer)
09/2010 - 03/2006
3Infections
01/2017 - 09/2012
3Carcinoma (Carcinomatosis)
09/2010 - 01/2008
3Hypoxia (Hypoxemia)
08/2010 - 01/2005
2Hepatocellular Carcinoma (Hepatoma)
12/2013 - 12/2010
2Fibrosarcoma
05/2007 - 04/2007
1Paraplegia (Spastic Paraplegia)
01/2022
1Brain Neoplasms (Brain Tumor)
01/2020
1Gout
01/2020
1Pain (Aches)
01/2020
1Paralysis (Palsy)
10/2018
1Inflammation (Inflammations)
01/2017
1Fibrosis (Cirrhosis)
09/2015
1Medulloblastoma
03/2014
1Measles
03/2014
1Cysts
12/2013
1Neoplasm Metastasis (Metastasis)
12/2013
1Carcinogenesis
01/2013
1Starvation
01/2013
1Breast Neoplasms (Breast Cancer)
01/2013
1Human Influenza (Influenza)
10/2012
1Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
10/2012
1Glioma (Gliomas)
09/2012
1Body Weight (Weight, Body)
08/2010
1Prostatic Neoplasms (Prostate Cancer)
05/2010
1Hyperplasia
06/2009
1Vascular Remodeling
06/2009
1Infarction (Infarctions)
05/2009
1Myocardial Infarction
05/2009

Drug/Important Bio-Agent (IBA)

7Cisplatin (Platino)FDA LinkGeneric
08/2010 - 03/2006
6Oxygen (Dioxygen)IBA
08/2010 - 09/2004
4Proteins (Proteins, Gene)FDA Link
03/2014 - 01/2008
4(3,5- bis((4- fluorophenyl)methylidene)- 1- ((1- hydroxy- 2,2,5,5- tetramethyl- 2,5- dihydro- 1H- pyrrol- 3- yl)methyl)piperidin- 4- one)IBA
09/2010 - 06/2009
3Antineoplastic Agents (Antineoplastics)IBA
09/2012 - 05/2010
3Pharmaceutical PreparationsIBA
06/2009 - 01/2008
3nitroaspirinIBA
02/2008 - 03/2006
2MicroRNAs (MicroRNA)IBA
01/2022 - 01/2013
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
12/2013 - 12/2010
2Superoxides (Superoxide)IBA
12/2010 - 05/2010
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2010 - 05/2009
2STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
08/2010 - 11/2009
2PiperidonesIBA
05/2010 - 05/2010
2Caspase 3 (Caspase-3)IBA
05/2010 - 05/2010
2Glutathione (Reduced Glutathione)IBA
08/2008 - 02/2008
2Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2008 - 03/2006
2Nitric Oxide (Nitrogen Monoxide)FDA Link
03/2006 - 06/2004
2lithium phthalocyanineIBA
01/2005 - 09/2004
1Choline O-Acetyltransferase (Choline Acetyltransferase)IBA
01/2022
1C-Reactive ProteinIBA
01/2020
1Biomarkers (Surrogate Marker)IBA
10/2018
1FluorocarbonsIBA
01/2017
1GadoliniumIBA
09/2015
1EndostatinsIBA
03/2014
1AngiostatinsIBA
03/2014
1Angiogenic ProteinsIBA
03/2014
1Angiogenesis InhibitorsIBA
03/2014
1Diethylnitrosamine (N-Nitrosodiethylamine)IBA
12/2013
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
12/2013
1Hormones (Hormone)IBA
01/2013
1Estrogen ReceptorsIBA
01/2013
1Estrogens (Estrogen)FDA Link
01/2013
1Biological ProductsIBA
01/2013
1Interleukin-6 (Interleukin 6)IBA
10/2012
1Antiviral Agents (Antivirals)IBA
10/2012
1pyrimidineIBA
10/2012
1Adenosine Triphosphate (ATP)IBA
10/2012
1tetrathiomolybdate (ammonium tetrathiomolybdate)IBA
09/2012
1CopperIBA
09/2012
1NestinIBA
02/2012
1MetallothioneinIBA
12/2010
1Free RadicalsIBA
12/2010
1Plasminogen Activator Inhibitor 1IBA
12/2010
1Focal Adhesion Protein-Tyrosine KinasesIBA
09/2010
1Mitogen-Activated Protein Kinase 3IBA
09/2010
1Messenger RNA (mRNA)IBA
09/2010
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
09/2010
1ErbB Receptors (EGF Receptor)IBA
09/2010
1Fatty Acid Synthases (Fatty Acid Synthase)IBA
09/2010
1Sterol Regulatory Element Binding Protein 1IBA
09/2010
1nitroxylIBA
05/2010
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
05/2010
1Hydroxylamine (Hydroxylamine Hydrochloride)IBA
05/2010
1AntioxidantsIBA
05/2010
1alpha,beta-diacryloxypropionic acid (DAPS)IBA
05/2010
1alpha- cyano- (3,4- dihydroxy)- N- benzylcinnamideIBA
11/2009
1Paclitaxel (Taxol)FDA LinkGeneric
11/2009
1Reactive Oxygen Species (Oxygen Radicals)IBA
11/2009
1NF-kappa B (NF-kB)IBA
06/2009
1Matrix Metalloproteinases (MMPs)IBA
06/2009
1TensinsIBA
06/2009
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
06/2009
1DisulfidesIBA
08/2008
1NCX 4040IBA
02/2008
1Sulfhydryl Compounds (Thiols)IBA
02/2008

Therapy/Procedure

4Therapeutics
01/2020 - 05/2010
2Radiotherapy
08/2010 - 09/2004
1Patient Readmission
01/2017
1Drug Therapy (Chemotherapy)
11/2009
1Transplantation
05/2009